The mutational analysis shows that primary sequences in the loop regions are important for function, suggesting that they may contain binding sites for cellular proteins involved in RNA export.
Interestingly, sequences with significant homology to the inner loop regions are found in the genomes of spumaviruses and mouse intracisternal A particles.
Publication types Research Support, Non-U. Secondary structure and mutational analysis of the Mason-Pfizer monkey virus RNA constitutive transport element. Curr Biol. A human nucleoporin-like protein that specifically interacts with HIV Rev.
A dispersed tyrosine tRNA gene from Xenopus laevis with high transcriptional activity in vitro. J Biol Chem. In vivo selection of RNAs that localize in the nucleus. Selection and nuclear immobilization of exportable RNAs. Monomethylated cap structures facilitate RNA export from the nucleus.
Regulation of retroviral RNA export. Regulation of human immunodeficiency virus env expression by the rev gene product. J Virol. Human immunodeficiency virus env expression becomes Rev-independent if the env region is not defined as an intron. Minimal Rev-response element for type 1 human immunodeficiency virus. RNA export. A cap-binding protein complex mediating U snRNA export.
Nuclear export of different classes of RNA is mediated by specific factors. Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm. U1 small nuclear RNA plays a direct role in the formation of a rev-regulated human immunodeficiency virus env mRNA that remains unspliced. Nonaqueous isolation of transcriptionally active nuclei from Xenopus oocytes. Methods Enzymol. Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function.
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes Dev. Nuclear export of proteins and RNAs. Curr Opin Cell Biol. Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.
Structural and functional characterization of the human immunodeficiency virus rev protein. J Acquir Immune Defic Syndr. A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1. Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation. Splice junctions, branch point sites, and exons: sequence statistics, identification, and applications to genome project.
Two-step affinity purification of U7 small nuclear ribonucleoprotein particles using complementary biotinylated 2'-O-methyl oligoribonucleotides. Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast. A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus.
The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function. A cellular cofactor for the constitutive transport element of type D retrovirus.
Retention and 5' cap trimethylation of U3 snRNA in the nucleus. Multiple cis-acting signals for export of pre-U1 snRNA from the nucleus. Identification of a signal for rapid export of proteins from the nucleus. Cooperative binding of R17 coat protein to RNA. A complex of nuclear proteins mediates SR protein binding to a purine-rich splicing enhancer.
Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif. Continuous propagation of RRE - and Rev - RRE - human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes. Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1.
Full text links Read article at publisher's site DOI : Foamy Viruses Are Unconventional Retroviruses. Journal of Virology. View 2 excerpts, references background. A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection. The EMBO journal. Our retroviral heritage. Trends in genetics : TIG. Morphogenesis and Maturation of Retroviruses. Current Topics in Microbiology and Immunology.
Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3. Related Papers. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy , Terms of Service , and Dataset License.
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